Needle Stick Injuries (NSI) resulted from accidental piercing of the skin and/ or muco-cutaneous membranes of health care workers. It also caused from suturing needles and other sharps used during clinical care. It is an occupational hazard in health care sector. Unsafe injections and procedures inviting risks to the health care workers. Adequate knowledge and adherence to safety of practices could prevent the occurrence of Needle S stick Injury. Among occupational injuries needle stick injuries are the largest problem in health care setting; Exposure to needle stick injury which have contact with blood and body fluids during health care procedures introduce them to various blood-borne diseases.