Maxillary sinus disease is common & numerous disorders can affect this anatomical area. As lesions are frequently allowed to grow to a significant size before becoming symptomatic, patients often present late, this can make management option more limited and difficult. Proper evaluation both clinically and with appropriate imaging allows accurate diagnosis, and lesion can often be successfully managed endoscopically. The radiographic anatomy of maxillary sinus and related structures are seen in Waters View, Sub Mento Vertex View and Caldwell View and more clear in 3D imaging technique especially Cone Beam Computed Tomography. Careful studies of these projections provide an excellent knowledge of the radiographic anatomy of maxillary sinus and its normal variants as well as different intrinsic & extrinsic pathologies involving it.