<p>This book constitutes the proceedings of the 13th International Conference on Information Security and Practice and Experience, ISPEC 2017, held in Melbourne, Australia, in December 2017. <br/> The 34 full and 14 short papers presented together with 9 papers from the SocialSec Track in this volume were carefully reviewed and selected from 105 submissions. The papers cover topics such as blockchain, asymmetric encryption, symmetric encryption, lattice-based cryptography, searchable encryption, signature, authentication, cloud security, network security, cyber-physical security, social network and QR code security, software security and trusted computing, and SocialSec track.</p>