This two-volume set of LNCS 12836 and LNCS 12837 constitutes - in conjunction with the volume LNAI 12838 - the refereed proceedings of the 17th International Conference on Intelligent Computing, ICIC 2021, held in Shenzhen, China in August 2021. The 192 full papers of the three proceedings volumes were carefully reviewed and selected from 458 submissions.<p>&nbsp;The ICIC theme unifies the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. The theme for this conference is "Advanced Intelligent Computing Methodologies and Applications."</p><p></p><p>The papers are organized in the following subsections: Artificial Intelligence in Real World Applications, Biomedical Informatics Theory and Methods, Complex Diseases Informatics, Gene Regulation Modeling and Analysis, Intelligent Computing in Computational Biology, and Protein Structure and Function Prediction.</p><br><p></p>