Pharmacology is only an assistance to the major endodontic procedure .The aim to treat any infection should be to start the treatment as soon as possible and relieve the patients from its symptoms. Antibiotics and analgesics should be used only in certain cases and should not be given to all patients. With utmost care and precaution the required effect and successful management of endodontic infections can be achieved with the righteous combination of endodontics and pharmacology.