Important test components for performance evaluation, including assessment of body composition, maximum aerobic capacity, heart rate and pulmonary function evaluation are worth considering. The purpose of this work was to assess the influence of skinfold thickness/body fat composition and some selected cardiopulmonary parameters on running performance in young Ethiopian middle distance athletes. Results of this work suggested that lower skinfold thicknesses and sub maximal heart rate were correlated with faster race time; higher some lung volume and aerobic capacity are also associated with faster run time.