The basis of human disease state is archaeal endosymbiosis. Archaeal endosymbiosis leads to disease states like neurodegeneration, neuropsychiatric disorders, oncogenesis, metabolic syndrome and autoimmunity. The endosymbiotic archaea secretes endogenous digoxin which plays a vital role in neuro-immuno-endocrine-genetic integration. Archaeal endosymbiosis leads to the human disease state and a monistic pathology for all human diseases. The monistic treatment of human disease state involves inhibition of archaeal endosymbiosis.