Orthognathic surgery is essential for syndromic patients with craniofacial deformities, aiming to correct functional and aesthetic issues caused by conditions like Crouzon, Apert, and Treacher Collins syndromes. These patients often face challenges such as speech, chewing, and breathing difficulties due to jaw malalignment. The surgery helps realign the jawbones to improve facial symmetry and function, including better speech and mastication. However, it involves complexities due to abnormal anatomy, limited bone and soft tissue, and potential coexisting medical conditions. Careful preoperative planning with advanced imaging and a multidisciplinary team is crucial. Common procedures include Le Fort osteotomy for the upper jaw, bilateral sagittal split osteotomy for the lower jaw, and distraction osteogenesis in cases of severe deformity. Postoperative care requires close monitoring for complications like infection or relapse and may involve further orthodontic treatment. Despite the challenges, orthognathic surgery can significantly improve the patient's quality of life by enhancing function, appearance, and preventing long-term complications.