Neuropsychological examination is an important way of formally assessing brain function. While there is so much documentation about the influence that some factors such as age and education has on neuropsychological tests (NP), not so much has been done to assess the influence that residency (rural/urban) may have. The specific objectives of this study were to establish if there is a significant difference in mean test scores on NP tests between rural and urban participants, to assess which tests on the Zambia Neurobehavioural Test Battery (ZNTB) are more affected by the participants' residency (rural/urban) and to determine the extent to which education, gender and age predict test performance on NP tests for rural and urban participants. This particular report is part of an ongoing larger cutting-edge study aimed at formulating the normative data for Zambia with regard to performance on neuropsychological tests.It has been shown in this study that it is vital to make careful analyses of the variables that may be associated with one's performance on neuropsychological tests.