This book provides a comprehensive and technical introduction to Python language. This book is written in beginner perspective and focused on fundamentals of Python and its implementation. This beginner friendly text book features plentiful ready to run programming examples and extensive explanation to understand difficult topics. The book includes Introduction to Programming in Python, Data types, Operators, different types of expressions. Python data structures like List, Dictionary, Tuple, Sets are covered with useful examples. Modular programming concepts such as user defined functions is also covered in this book. Readers will find complete programming code and clear display of syntax, explanation, and examples easy to read and beneficial to learning. This book is useful for one semester course focused on Python.