Central giant cell granuloma (CGCG) is a Benign, locally aggressive, nonodontogenic, lesion of the jaw. The ubiquitous presence of giant cells in numerous unconnected bony lesions makes differential diagnosis even more difficult. Clinical, radiological, and, most importantly, biochemical and anatomopathological factors all play a role in the diagnosis of CGCG. This textbook contains a detailed description of CGCG with a list of diffrential diagnoses and latest treatment modalities