Spatiotemporal Modeling of Cancer Immunotherapy
ISBN: 978-30-301-7636-5
Format: 15.6x23.4cm
Liczba stron: 124
Oprawa: Miękka
Wydanie: 2020 r.
Język: angielski
Dostępność: dostępny
<p>The focus of this book is a detailed discussion of a dual cancer vaccine (CV)-immune checkpoint inhibitor (ICI) mathematical model formulated as a system of partial differential equations (PDEs) defining the spatiotemporal distribution of cells and biochemicals during tumor growth.</p><p>A computer implementation of the model is discussed in detail for the quantitative evaluation of CV-ICI therapy. The coding (programming) consists of a series of routines in R, a quality, open-source scientific computing system that is readily available from the internet. The routines are based on the method of lines (MOL), a general PDE algorithm that can be executed on modest computers within the basic R system. The reader can download and use the routines to confirm the model solutions reported in the book, then experiment with the model by varying the parameters and modifying/extending the equations, and even studying alternative models with the PDE methodology demonstrated by the CV-ICI model.</p><p><i>Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R</i> facilitates the use of the model, and more generally, computer- based analysis of cancer immunotherapy mathematical models, as a step toward the development and quantitative evaluation of the immunotherapy approach to the treatment of cancer.</p><p>To download the R routines, please visit: http://www.lehigh.edu/~wes1/ci_download<br></p><p></p>