Periodontal regeneration involves both clinician expertise and the selection of suitable regenerative materials and techniques. Over the past 25 years, significant research has focused on evaluating various surgical techniques, with advancements in periodontal tissue engineering and regenerative medicine shaping the field. Future innovations may include biomimetic scaffolds that deliver biologics based on cellular demands and 3D-printed organs.Key research priorities include identifying optimal growth factor concentrations, understanding their effects on hard and soft tissue components, and exploring tissue engineering approaches that combine biologics with sequential and controlled delivery. Additionally, creating interconnected, porous scaffolds with proper biomechanical properties and improving cell therapy techniques will enhance regenerative outcomes. Ultimately, these advancements aim to provide personalized treatment options that enhance function, aesthetics, and patient care quality.