The term markup means 'a detailed instruction, usually written on a manuscript to be typeset, concerning style of type, makeup of pages, and the like'. Markups basically implements the idea of typesetting, i.e. 'designing fonts for characters and arranging them in some order'. The descendants of various text markups include development of markup languages such GML, SGML, HTML and XML. This book intends to target students, scientists, researchers who which to use markups in handling their biological data. The first focus in on Chemical Markup Language (CML), a language for representing chemical data. This is followed by explicit information on Bioinformatics Sequence Markup Language (BSML), used for storing an handling sequence-based biological data. The last section of the book deals with handling Systems Biology data by introducing and explaining Systems Biology Markup Language (SBML).