Soil-transmitted helminths infections remain a common public health concern among children in developing tropical countries and these parasitic infections are highly prevalent in Africa. The problem is predominant among children, and is often associated with poor growth, reduced physical activity, impaired cognitive function and learning ability. This study was conducted to provide information upon investigation of infection by evaluating the prevalence of soil transmitted helminths infection based on gender and age among children of Blessed Hope and Faith Orphanage in Calabar-South, Cross River State, Nigeria. This study investigates the prevalence of soil-transmitted helminths infections among children at an orphanage in Nigeria, revealing a 100% infection rate among the sampled population. The findings highlight the urgent need for improved sanitary facilities, provision of deworming drugs, and promotion of proper hygiene practices to address this public health concern.