Infiltrating lobular carcinoma (ILC) of the breast is a rare histological entity, accounting for between 5% and 15% of all breast cancers.It is classified as the second most frequent histological type, after non-specific infiltrating cancer (NIC). The aims of our work were to describe the anatomo-clinical particularities and therapeutic modalities, to specify the role of breast imaging in the positive diagnosis and to identify the main prognostic factors.We carried out a retrospective descriptive study of 30 observations of CLI of the breast collected in the Obstetrics and Gynaecology Department of the Monastir Maternity and Neonatology Centre over a 10-year period. The incidence of CLI in our study was 4%. The mean age at onset of CLI was 53.43 years. A breast nodule was the most frequent revealing sign, characterized by multifocal and bilateral lesions, hence the importance of MRI. CLI appears to have a good prognosis, as it is often of low histopronostic grade, and its mode of evolution is often insidious, with positive hormone receptors in the majority of cases.