U.S. leadership in global health advances core U.S. interests. It fulfills shared humanitarian values by saving and enhancing lives. It strengthens health security against common and emerging threats. And it promotes stability and prosperity in far-flung communities in the developing world who strive for better health and better lives for their families. For all these reasons, supporting global health should remain a U.S. government and budget priority-and as the second Obama administration and incoming Congress commence their work, this collection of essays offers pragmatic, informed guidelines for seizing the opportunities ahead.