This book constitutes the refereed proceedings of the 22nd International Symposium on Stabilization, Safety, and Security of Distributed Systems, SSS 2020, held in Austin, TX, USA, in November 2020.<p>The 16 full papers, 7 short and 2 invited papers presented were carefully reviewed and selected from 44 submissions. The papers deal with the design and development of distributed systems with a focus on systems that are able to provide guarantees on their structure, performance, and/or security in the face of an adverse operational environment.</p>